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EchoMRI™ 清醒小動物體脂肪水份分析儀-肥胖,内分泌和代

EchoMRI™ Quantitative Magnetic Resonance Body Composition Analyzers for animals and humans take direct measurements of total body fat, lean mass, free water, and total body water. The measurement principle depends on the density of hydrogen nuclei and the physical state of the tissue.

More rapid, accurate, and precise than other methods, EchoMRI™ technology allows for fast measurements (about 1min for mice and rats and less than 3min for humans) in vivo without anesthesia or sedation. Unlike DEXA, Echo measurements are radiation-free, do not require the subject to remain still, and in a peer-reviewed study yielded 24 times DEXA's precision facilitating convenient, low-stress repeated tracking of small changes in body composition. Moreover, Echo instruments measure fat and lean mass as an independent characteristics, unlike DEXA, which measures the fat to lean ratio and is, therefore, prone to error propagation from lean to fat. The systems are much less expensive than conventional MRI, are completely silent, and do not require advanced training to use.

In short, EchoMRI™ is the only technology on the market today which allows body composition analyses to be conducted in such a short period of time, with such a high level of precision, without the need for anesthesia or sedation of the test subject(s), with the subjects entirely comfortable during and in preparation for the measurement, and with no radiation to be considered as a health issue.

特色:

  1. 極佳的準確度、敏感度: 核磁共振的定量技術 (Quantitative Neuroscience with Magnetic Resonance),可精準的分析體各成份""數的儀器
  2. 不需麻醉: 可掃描活體清醒動物
  3. 可做in-vivoex-vivo的測試
  4. 檢測時間快速:約1 min就可測得                                  
  5. 安全性高:不需任何防護及特殊防護空間

功能: 

The EchoMRI™ proprietary method for tissue characterization provides measurements of whole body composition parameters: fat mass, lean tissue mass, free water, and total body water. The data obtained by EchoMRI™ are highly correlated to those obtained by DEXA, but the measurement procedure is faster and does not require anesthesia. In fact, the measurement duration is about 1 minute for mice and rats and about 3 minutes for humans.

1.   可測的體成分參數:

  • 全身脂肪克數 Total Body Fat ;
  • 瘦肉組織克數 Lean Tissue Mass
  • 全身含水量 Total Body Water;
  • 體液克數 Free Body Fluids

2.   可測的對象: 活體清醒動物、死亡動物及組織檢體,包括了: MiceRat,大動  物,人,斑馬魚,昆蟲,種子,TissueBiopsy .

3.   可應用於肥胖症、糖尿病及新陳代謝疾病等研究

EchoMRI™: features and benefits

The key benefit of the EchoMRI™ systems to those involved in research is the precision and accuracy they offer when compared to those of DEXA. When Nuclear Magnetic Resonance (NMR) is applied toward the analysis of body composition during clinical trials, it has an effect on the accuracy, precision, sensitivity, and specificity of results. It is far superior in its ability to offer precise and accurate results for researchers and clinicians.

 
Precision: Precision of fat measurement by EchoMRI™ in mice i about 25 times higher than DEXA. This higher precision allows researchers to reduce considerably the number of treated subjects and controls during drug development and testing.
 
Sensitivity: The high sensitivity of EchoMRI™ allows less compound to be administered for each animal while achieving a measurable response. Statistically significant detection of differences of small magnitude in body composition allows the dose of a tested compound to be reduced, and therefore, substantially reduces its toxicity effect.
 
Specificity: The high specificity of EchoMRI™ technology isolates and focuses on the accurate measurement of fat content instead of less relevant non-disease parameters, such as body weight or nonfat masses. The specificity of EchoMRI™ measurement is based on molecular physical principals, unlike any of its competitors, and unlike DEXA, all measured parameters are easy to interpret.
 
Accuracy: The EchoMRI™ whole body composition analyzer is designed to provide high accuracy for screening, while DEXA and other technologies have low accuracy capabilities. On the other hand, with DEXA, subjective threshold values can cause subjective results. Live and dead animals have large differences in values. The equipment cannot be calibrated against 100% fat or lean, introducing errors. The fat and lean in the head is omitted from results, and the spine core fat is under-detected. On a DEXA projection, 40% of the image is covered by bone, so there are large errors in fat and lean measurements.
 
No Need for Anesthesia or Sedation: EchoMRI™ measurement of moving bodies is non-invasive, with no anesthesia or sedation required. Animals are able to move freely. Thus, having no need for anesthesia or sedation saves time and reduces the 2-day impact on animal behavior from gas or injected anesthesia required for DEXA.
 
Fast Measurements: The measuring technique is optimized for the maximum measuring precision of whole body fat, muscle, and body fluids, while keeping the total measurement time to about one minute for rats and mice. With DEXA, the time of measurement is 5 minutes, and preparation and recovery for each animal can take up to 2 days.
 
Safety: The static magnetic field is completely shielded and this prevents containment issues in the outside and internal environment, including the internal shielding of radio frequency (RF) magnetic and electrical fields. DEXA x- ray equipment requires adherence to regulations.

 

機款 Models:

產品名稱

EchoMRI-100

EchoMRI 3-in-1

EchoMRI-700

EchoMRI-900

EchoMRI Custom

EchoMRI-AH

動物型態

Mice

Mice

Rats

Various animals

Humans

體重範圍

<100 g

活體動物: 15~100 g

組織樣品: 0.2~15 g

組織切片: 10~500 mg

EchoMRI-700:100~700 g

EchoMRI-900:250~900 g

可測不同的體重範圍及大小

60 kg~250kg

測量時間

< 1 min

< 1 min

< 1 min

<1 min

<10 min

檢測項目 (g)

全身脂肪量total body fat

瘦肉量lean muscle mass

全身含水量total body water

體液含量body fluids

·  活體動物:

  瘦肉量lean muscle mass

  全身脂肪量total body fat

  全身水量total body water

  游離體液free body fluids

·  組織樣品:

  脂肪fat

  非脂肪組織lean tissue

  游離液體free fluids

·  組織切片:

  脂肪fat

  非脂肪組織lean tissue

  游離液體free fluids

全身脂肪量total body fat

瘦肉量lean muscle mass

全身含水量total body water

體液含量body fluids

全身脂肪量total body fat

瘦肉量lean muscle mass

全身含水量total body water

體液含量body fluids

全身脂肪量total body fat

瘦肉量lean muscle mass

全身含水量total body water

體液含量body fluids

 

Frequently Asked Questions about EchoMRI™ systems


Q. Does the machine generate heat? If so, how much?
A. The device has five core components: a magnet, sensor assembly, analog electronics, digital electronics, and an LCD monitor. The Rat/Mouse magnets are permanent, not electromagnets, and, therefore, generate no heat. The Adult Human magnet is an electromagnet but generates a relatively small amount of heat, equal to a computer workstation. The operation of the antenna assembly generates a negligible amount of heat. The analog electronics box generates a small amount of heat so that the box does not even need a fan. The most heat generated by the instrument comes from the digital electronics, which has a standard computer-type fan that exhausts about as much heat as a typical personal computer or a typical light bulb. In a normal laboratory environment, no special air conditioning or environmental settings are required.

Q. What are the safety issues with EchoMRI™? What is the magnetic field in the vicinity of the EchoMRI™ system? Is any special shielding required?
A. No special shielding is required. For the Rat/ Mouse/ 3-in-1 systems, the magnetic field induction is less than 5 X 10-4T, excluding volume that is less than 9" (0.2m) from the gantry. The Adult Human system has a 5-gauss field that extends approximately 65"/ 26cm from the magnet covers.

Q. What are the features and benefits of EchoMRI™ systems?
A. The key benefit of the EchoMRI™ systems to those involved in research is the precision and accuracy they offer when compared to those of DEXA. When Nuclear Magnetic Resonance is applied toward the analysis of body composition during clinical trials, it has an effect on the accuracy, precision, sensitivity, and specificity of results. It is far superior in its ability to offer precise and accurate results for researchers and clinicians.

 

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