The Lorrca® Maxsis osmoscan (Lorrca®)


: Lorrca激光衍射红细胞变形分析仪 从最小的静脉血测量红细胞 或 红细胞(RBC)在剪切应力下的伸长。


  • 红细胞可变形性; 延伸率是剪切应力的函数

  • RBC Osmoscan; 延伸率作为渗透压的函数

  • RBC Oxygenscan; 延伸作为脱氧和随后的复氧的功能

  • 红细胞聚集&反聚集; 聚合是时间/剪切速率的函数


    :氧合扫描是在添加pO2Scan后,可以在Lorrca ektacytometer平台上进行的测量。它测量红细胞在受控脱氧和复氧过程中的伸长。

    :所有的Lorrca仪器都能通过Lorrca Po2Scan进行创新吗?

    :2012年开始使用的Lorrca MaxSis Osmoscan仪器可以与PO2Scan互补。


    : 是的,当PO2Scan安装在仪器上时,还可以进行变形性测试、渗透测试和聚集&反聚集测试。


    变形能力测试需要1分钟。渗透扫描测试需要app. 6分钟,氧扫描测试需要app. 20分钟(Lorrca信息)








    :变形能力测试是25 ul血液样本。渗透压试验为200 ul,氧合扫描试验为50 ul(参见Lorrca信息)







Laser Optical Rotational Red Cell Analyzer

Lorrca Maxsis osmoscan (Lorrca®) is a unique instrument which combines Red Blood Cell (RBC) deformability by ektacytometry, osmoscan and aggregometry; all temperature controlled. It is capable of fully automated measurement and calculation of various phenomena of RBC’s by analysis of their rheological behavior. The technique accurately detects deformability as a function of shear stress, pre-hemolytic stability and aggregation of the RBC’s and is of added value for hematology analysis.

  • Scope

    Possible measurements of the instrument
    Evaluation of the rheology of blood in different parts of the body is a very specific task, therefore it is important to have a technique available that can accurately measure the RBC properties. Lorrca incorporates a variety of techniques to perform these specific measurements:

    • Deformability: Laser diffraction ektacytometry, Parameterization of deformation curve, Cell- and cell membrane stability
    • Osmoscan: Deformability under an osmotic gradient, Osmotic Resistance Test
    Aggregation & dis-aggregation: Syllectometry – Extent of aggregation, aggregation kinetics and tendency
    • Oxygenscan; Measuring the relative oxygen pressure at the critical point the red blood cells start to sickle

  • Deformability

    Red blood cell deformability, expressed as the Elongation Index (El), is presented in a deformability curve. A thin layer of RBC’s, suspended in PVP, is sheared between two concentric cylinders. A known shear stress is applied to the cells, resulting in the elongation (deformation) of the RBC’s. This process is measured by a laser beam diffraction pattern; captured with a video camera and analyzed by a computer.

    RBC deformability curve



    The osmoscan measures the RBC deformability under various osmotic conditions. This results in a continuous curve.


    Lorrca<sup>®</sup> Osmoscan

    Typical osmoscan curves


    Aggregation & dis-aggregation

    Lorrca measures the speed at which rouleaux formation occurs and is presented in a syllectogram. By means of a photodiode (which measures the change in light absorption) the tendency and kinetics of aggregation are displayed, as well as the minimal shear rate (threshold) needed to prevent RBC aggregation.

    RBC Syllectrogram



    consists of one instrument for a whole range of different red blood cell (RBC) applications

    • Automated testing
    • Easy data generation
    • High quality data
    • Quick protocols generate results within minutes
    • Unique technology
    • Easy-to-Use
    • Table top size