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LABORAS and SONOTRACK from Metris
[ 作者:佚名 | 来源:本站原创 | 点击数:3833 | 更新时间:2009-01-26  ]

LABORAS

Laboras System

LABORAS is an advanced and completely non-invasive system that automatically recognizes several normal and special behaviors of rats and mice by analysis of the forces that are induced by the movements of the animal.

LABORAS determines the following validated behaviors and information of mice and rats:

Normal behaviors

Group 1 (basic)
  • Climbing (in mice)
  • Locomotion 
  • Immobility
  • Rearing
Group 2 (advanced)
  • Grooming
  • Drinking
  • Eating

Special Behaviors

  • Scratching (in mice)
  • Seizures: Barrel rolls &
    Tonic Clonic (in mice)
  • Seizures: Racine scale
    P4 & P5  (in mice) 
  • Purposeless chewing (in rats)
  • Hindlimb licking (formalin test in rats)
  • Wet Dog Shakes (in rats)
  • Head shakes (in rats)
  • Head twitches (in rats) 

Tracking information

  • Position (X,Y)
  • Speed
  • Avg. speed
  • Max. speed
  • Time of max. speed 
  • Traveled distance
  • Position distribution
  • Nr. of circles (CW and CCW)
  • Avg. time in circle
  • Avg. speed in circle
  • Avg. circle size

 

Presentations

Product Presentation Metris

LABORAS: Comparison with the competition

LABORAS expensive? Examples how to earn money with LABORAS

 

Papers

Importance of Energy parameter in Preclinical Research

Product videos

Download the LABORAS promotion video

See the Laboras performance yourself.
(LABORAS detection and Video Integrated)

Example 1: Head Twitch detection in rats

Example 2: Wet Dog Shakes detection in rats

Example 3: Normal behavior detection in rats

Example 4: Circling behavior detection in rats

If you have a problem to play the videos, please download the xvid codec. 

SONOTRACK

 

Sonotrack is an advanced non-invasive measurement system to record, analyze and playback ultrasound vocalizations (USV) of animals. Sonotrack is designed to record the full spectrum of animal vocalizations from 15 kHz to 100 kHz without the need of pre-tuning. The extremely low-noise amplifiers enable recording of ultrasounds that were previously impossible with other systems.

Unlike other systems, it not only detects the presence of USV but provides detailed information about the vocalization signals too. Sonotrack not only records and converts the ultrasounds in a for humans audible signal but also provides several graphical presentations of the recorded sounds. The automatic Ultrasound Vocalization Counter makes it possible to analyze your recorded signals automatically and reliably, saving a lot of time. 
 

Sonotrack Specifications

SONOTRACK is designed for and with the help of laboratory animal researchers, which has resulted in a system that is easy to use and matches your research needs.

Microphone(s)

  • Type:
    Gold Foil Electrostatic Transducer Microphone
  • Freq range:
    15kHz - 100kHz (can be extended with additional micr.)
  • Minimum Receiving Sensitivity:
    -42 dB @ 50kHz
  • Beam Angle:
    12 degr. @ 3dB down
  • Operating conditions:
    Temp 32 - 140 F, Humid 5 - 95%

Software

  • Computer:
    Pentium-Duo Core 2 GHz and up, min. 2048 MB of RAM, HD 120 GB or up
  • Operating System:
    Preferred: Windows XP Professional, Windows Vista
  • Number of recordable channels:
    4 different channels (8 channels in development)
  • User interface:
    Windows compatible
  • Data accessibility:
    Integrated data presentation and export capabilites to other Windows packages

Electronics

  • A/D Conversion:
    A/D conversion card for the PC (suited to collect 4 channels with frequencies of up to 100 kHz continuously)
    Alternative low-cost A/D conversion card (suited to collect 1 channel with frequencies of up to 100 kHz continuously)
  • Bias Voltage Generator:
    Generates a stable bias voltage 200 +/- 1V used by the Mircophones
  • Signal Conditioning:
    8th order analog bandpass filter that reduces unwanted frequencies under 15kHz and above 100kHz and tuned for use with the SONOTRACK Microphones

Output definitions

  • Sound Files:
    ".dat files" (internal SONOTRACK format to store sound data)
    ".wav files" (compatible with commonly used media player software)
  • Sound Graphics:
    Pasting of graphics to other Windows applications via Clipboard
    Direct printing to any printer 


icon_movie.jpg

Video Clip about Rat Ultrasound Vocalizations
(copyrights Oxford University - Dr. M. Berdoy)

icon_movie.jpg
Promotion Video of SONOTRACK

 

icon_pdf.gif
Types and Functions of Ultrasonic Vocalizations in Laboratory Rats and Mice
(Copyrights the American Association for Laboratory Animal Science - Christine V Portfors)

Laboras Publications

2009

bullet2.gif Bison, S.; Carboni, L.; Arban, R.; Bate, S.; Gerrard, P.A.; Razolli, M.;
Differential behavioral, physiological, and hormonal sensitivity to LPS challenge in rats
International Journal of Interferon, Cytokine and Mediator Research 2009:1, page 1-13 (2009) Full article

2008

bullet2.gif Woolley, M.L.; Pemberton, D.J.; Bate S.; & Corti, C.; Jones, D.N.C.
The mGlu2 but not the mGlu3 receptor mediates the actions of the mGluR2/3 agonist, LY379268, in mouse models predictive of antipsychotic activity
Psychopharmacology, (2008) 196:431–440 Full article
bullet2.gif Wood, N.I.; Goodman, A.O.; Van der Burg, J.M.; Gazeau, V.; Brundin, P.; Björkqvist, M.; Petersén, A.; Tabrizi, S.J.; Barker, R.A.; Morton, A.J.;
Increased thirst and drinking in Huntington's disease and the R6/2 mouse
Brain Research Bull, 76 (1-2):70-9 (2008) Full article
bullet2.gif Inglis, J.J.; McNamee, K.E.; Chia, S.; Essex, D.; Feldmann, M.; Williams, R.O.; Hunt,S.P.; Vincent, T.
Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system
Arthritis & Rheumatism Vol. 58, Issue 10, Pages 3110 -3119 (Sept. 2008) Details
bullet2.gif Avsaroglu, H.; Sommer, R.; Hellebrekers, L.J.; Van Zutphen, L.F.M.; Van Lith, H.A.;
The effects of buprenorphine on behaviour in the ACI and BN rat inbred strains
Laboratory Animals, 42 (2008), Page 171-184 Detail
bullet2.gif Van der Burg, J.J.M.; Bacos, K.; Wood, N.I.; Lindqvist, A.; Wierup, N.; Woodman, B.; Wamsteeker, J.I.; Smith, R.; Deierborg, T.; Kuhar, M.J.; Bates, G.P.; Mulder, H.; Erlanson-Albertsson, C.; Morton, A.J.; Brundin, P.; Petersén, A.; Björkqvista, M.
'Increased metabolism in the R6/2 mouse model of Huntington's disease'
Neurobiology of Disease, 29 (2008), Page 41-51 Full article
bullet2.gif Franěk, M.; Vaculín, Š.; Rokyta, R.
'Changes of locomotor activity in animal models of neuropathic pain'
12th World Congress on Pain, Glasgow, Scotland (August 2008) Poster
bullet2.gif Hedenqvist, P.
'Anaesthesia and analgesia for surgery in rabbits and rats, a comparison of the effects of different compounds'
Doctorial Thesis, Karolinska Institutet, Stockholm (2008), ISBN: 978-91-7357-578-2 Full report

2007

bullet2.gif Nagelkerken, L.; Verzaal, P.; Lagerweij, T.; Persoon-Deen, C.; Havekes L.; Oranje, A.P.
'Human apolipoprotein C1 transgenic mice: a unique model of atopic dermatitis.'
Poster (AD 2007) Full Poster
bullet2.gif Avsaroglu, H.; Sommer, R.; Hellebrekers, L.J.; Van Zutphen, L.F.M.; Van Lith, H.A.
'Differences in the behavioural response to buprenorphine between the ACI and BN rat inbred strains'
Poster 10th FELASA Symposium, June 11-14, 2007 Cernobbio Full Poster
bullet2.gif Van Loo, P.L.P.; Kuin, N.; Sommer, R.; Avsaroglu, H.; Pham, T.; Baumans, V.
'Impact of "living apart together" on postoperative recovery of mice compared with social and individual housing.'
Laboratory Animals (2007) Full article
bullet2.gif Inglis, J.J.; Notley, C.; Essex, D.; Wilson, A.W.; Feldmann, M.; Anand, P.; Williams, R.
'Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of TNF blockade.'
Arthritis & Rheumatism (29 November 2007) Vol 56, Issue 12, Pages 4015-4023 Details
bullet2.gif Erschbamer, M.; Pernold, K.; Olson, L.
'Inhibiting Epidermal Growth Factor Receptor Improves Structural, Locomotor, Sensory, and Bladder Recovery from Experimental Spinal Cord Injury'
The Journal of Neuroscience (June 13, 2007) Vol. 27, Issue 24, Page 6428–6435 Full Article
bullet2.gif Medhurst, A.D.; Briggs, M.A.; Bruton, G.; Calver, A.R.; Chessell, I.; Crook, B.;, Davis, J.B.; Davis, R.P.; Foley, A.G.; Heslop, T.; Hirst,
W.D.; Medhurst, S.J.; Ociepka, S.; Ray, A.; Regan, C.M.; Sargent, B.; Schogger, J.; Stean, T.O.; Trail, B.K.; Upton, N.; White, T.; Orlek, B.;
Wilson, D.M.

'Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced
secondary allodynia in rats'
Biochemical Pharmacology (15 April 2007) Vol. 73, Issue 8, Page 1182–1194
bullet2.gif Chicurel, M.
'HD2006: Changes, Advances, and Good News (CAG)'
Summary Report of the Heredity Disease Foundation Symposium 2006 (published February. 2007) Full report
bullet2.gif Pugha, P.L.; Richardson, J.C.; Bate, S.T.; Upton, N.; Sunter, D.;
'Non-cognitive behaviours in an APP/PS1 transgenic model of Alzheimer's disease'
Behavioural Brain Research (2007), Vol 178, Page 18-28 (available Jan. 2007) Full article
bullet2.gif Aberg, E.
'On Regulation of Hippocampal Neurogenesis: Roles of Ethanol Intake, Physical Activity and Environment'
Doctorial Thesis, Karolinska Institutet, Stockholm (2007), ISBN: 978-91-7357-439-6 Full report

Sonotrack Publications

2009

bullet2.gif Takahashi, A.; Yap, J.J.; Zitzman Bohager, D.; Faccidomo, S.; Clayton, T.; Cook, J.M.; Miczek, K.A.
Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups
Psychopharmacology (2009) 204:61–71 Full article

2005..2008

bullet2.gif Hansen, E.; Agmo, A.;
Precopulatory Ultrasonic Vocalizations in Rats: Noise or Communications?
Poster University of Tromsoe (2006) Poster
bullet2.gif Portfors, C.V.;
Types and Functions of Ultrasonic Vocalizations in Laboratory Rats and Mice
Journal of the American Association for Laboratory Animal Science (2007) Full article
bullet2.gif

Oliveira, A.R.; Barros, H.M.T.
'Ultrasonic Rat Vocalizations During the Formalin Test: A Measure of the Affective Dimension of Pain?'
Anesthesia Analg 2006;102:832–9 (2006) Full article

bullet2.gif Metris b.v. / Dr. Ellen Molewijk
'High Quality Simultaneous Measurements of Rodents Behaviour, Tracking, Physiology, Sleep Stages and Ultrasounds'
Touch Briefings, Future Drug Discovery 2006, (report January 2006) Full article
bullet2.gif

Holy, T.E.; Guo, Z.
'Ultrasonic Songs of Male Mice'
PLoS Biology Dec. 2005, Vol 3, Issue 12, e386 (2005) Full article

bullet2.gif Metris b.v. / Dr. Ellen Molewijk
'High Quality Measurements of Rodents Behaviour, Tracking and Ultrasounds Using LABORAS and SONOTRACK'
Touch Briefings, Future Drug Discovery 2005, (report January 2005) Full article

 

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