The MASCIS Impactor is a device designed to deliver graded reproducible spinal cord contusions in rats.
Developed over ten years ago, the Impactor is part of a well-defined rodent spinal cord injury model that is used in over 100 laboratories around the world. Most of the recommended procedures for the Impactor are based on experience with the model and work done by the Multicenter Animal Spinal Cord Injury Study (MASCIS). The Impactor is now in its third generation with many improvements over previous models.
The MASCIS Impactor, formerly called the NYU Impactor, was developed in 1991 by Drs. John Gruner, Carl Mason, and Wise Young. It is now used in laboratories throughout the world in their spinal cord injury studies. The device precisely
measures the movement of a 10-gram rod dropped 12.5, 25.0, or 50.0 mm onto the T9-10 spinal cord exposed by laminectomy. In addition, the device measures movement of the spinal column at the impact site, displays the trajectory of the falling rod, and measures the impact velocity (ImpV), cord compression distance (Cd), cord compression time (Ct), and cord compression rate (Cr). These impact parameters correlate with each other and spinal cord lesion volumes (estimated from tissue Na and K concentrations) and locomotor recovery (BBB scores).
In addition, NYU Impactor allows the end user to measure below parameter:
Impact velocity (ImpV)
cord compression distance (Cd)
cord compression time (Ct)
cord compression rate (Cr)
Clamping systems are available for both rat and mice. A clamping system is necessary for NYU Impactor. When Using Clamping system, a CS-tie device is needed.
The MASCIS Impactor is 17” high x 12” deep and 10” wide.
It weighs approximately 11 pounds.
The MASCIS Impactor is a device designed to deliver graded reproducible spinal cord contusions in rats. Developed over ten years ago, the Impactor is part of a well-defined rodent spinal cord injury model that is used in over 100 laboratories around the world. In addition, more than 50% of recent publications on spinal cord injury research used the MASCIS Impactor. Most of the recommended procedures for the Impactor are based on experience with the model and work done by the Multicenter Animal Spinal Cord Injury Study (MASCIS).
The Impactor is now in its third generation with many improvements over previous models. It is available in a model with data recording capability (description and picture links) which requires a Pentium computer. It is also available in a basic model (The Rutgers Impactor) which only does the impact, not the recording of data.
Clamping systems are available for both rat and mouse. A clamping system is necessary for the Rutgers basic model and serves as a functional enhancement for the MASCIS model. When using a clamping system with the MASCIS model, a CS-tie device also is needed.
J Neurotrauma. 2009 Feb 9.
Dankook University College of Medicine, Rehabilitation Medicine, San 16-5 Anseo-dong, Cheonan, Korea, Republic of, 330-714, 82-41-550-6640, 82-41-551-7062; firstname.lastname@example.org.
The aims of this study were to evaluate the evolution of the neurogenic bladder after spinal cord contusion, and to correlate changes in bladder function with locomotor function and levels of neurotrophic factors. The MASCIS impactor was used to cause a mild contusion injury of the lower thoracic spinal cord of Sprague-Dawley rats. Rats were divided into four groups according to the length of time from injury to sacrifice, at 4, 14, 28, and 56 days after injury. Gait analysis was performed each week, and urodynamic study was performed just before sacrifice. Basso, Beattie, and Bresnahan (BBB) and coupling scores showed gradual recovery, as did the urinary voiding pattern and bladder volume; some parameters of micturition reached normal ranges. Brain-derived neurotrophic factor (BDNF) levels in the spinal cord, as detected by enzyme-linked immunosorbent assay, decreased with time, whereas neurotrophin-3 (NT-3) levels remained unchanged. The micturition pattern, bladder volume and locomotor function continued to recover during the time of observation; BDNF levels in the spinal cord and bladder were inversely correlated with BBB scores and the restoration of bladder volume. We conclude that urodynamic changes in the bladder correlate with locomotion recovery but not with the levels of BDNF or NT3 after modified mild contusion injury in rats.
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