唯一的呼吸功能监测研究系统SCIREQ Scientific Respiratory Equipment Inc. are designed to provide a flexible working environment for scientists in pulmonary research. The list of applications shown below is merely a sample out of the wide range of possible applications and is by no means intended to be complete.
十多年以来, 采用SCIREQ Scientific Respiratory Equipment 进行呼吸生理及药理研究的全世界顶尖的研究机构和大学及药厂研究室已达一百余家。 生命科学实验研究发表的科学论文2007年已达一百多篇
Cyclooxygenase-1 2006 J Immunol.pdf。
flexiVent 12 2007 _Chinese_.pdfAHMSIC (Respiratory Research 2006).pdf Flexivent IAM.pdf
flexiVent动物呼吸动力参数测定系统组成及原理：
flexiVent动物呼吸动力参数测定系统因采用了强力振动测定呼吸阻力的技术，可将雾化吸入装置与反应气道收缩程度的阻力测定装置及计算、显示、记录装置并为一体，并使吸入诱发剂与呼吸阻力的测定可同时、不间断地进行, 且不受吸气动作的干扰，快速、安全测定剂量－反应曲线，同时测定气道敏感性和气道反应性, 测试数据客观，准确且一致性高。
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•Asthma & airway hyperresponsivenss (AHR)•Chronic obstructive pulmonary diseases (COPD)•Fibrosis; ARDS/IRDS; Acute Lung Injury;•Basic Research; Phenotyping•Drug Development; Safety Pharmacology•Ventilator Research
Pulmonary Research Applications
Animal Models动物模型
� The development of viable animal models is an important step towards better understanding many diseases. Our ability to evaluate and characterize an animal model highly depends on the quality of the measurement tools we use.
Central vs. Peripheral呼吸中枢与外周比较
� Detailed measurements of respiratory mechanics allowing a separation of central and peripheral mechanics ("airways vs. tissues") offer additional insights in many areas of pulmonary research.
Drug Screening药物筛选
� One of the most important aspects of screening prospective drug compounds is efficiency. However, true efficiency is more than just the ability to measure many animals in a short time.
Late Response迟后反应
� The study of the Asthmatic Late Response is challenging because it requires good measurement sensitivity over the full duration of protocols that can last several hours.
Clinical Research临床研究
� Data collection in the OR and the ICU is often a waiting game where much time is spent to record sometimes only a single episode. Reliable equipment and clean signals are key to ensuring the integrity of these precious data.
Measurements & Outcome Parameters监测及计算参数
| Parameter | Abbr. | Description |
|---|---|---|
| Resistance | R | Dynamic resistance quantitatively assesses the level of constriction in the lungs. |
| Compliance | C | Dynamic compliance captures the ease with which the lungs can be extended. |
| Elastance | E | Dynamic elastance captures the elastic rigidity of the lungs. |
| Input Impedance | Z | Input Impedance expresses the combined effects of resistance, compliance and inertance as a function of frequency. |
| Resistance vs. frequency | R(f) | The real part of input impedance (Z) can be expressed as resistance versus frequency. |
| Reactance vs. frequency | X(f) | The imaginary part of input impedance (Z) can be expressed as reactance versus frequency. |
| Newtonian Resistance | Rn | The Newtonian Resistance parameter of the Constant Phase Model represents the resistance of the central airways. |
| Inertance | I | The Inertance parameter of the Constant Phase Model represents the inertive properties of the gases in the airways. |
| Tissue Damping | G | Tissue damping is closely related to tissue resistance and reflects the energy dissipation in the lung tissues. |
| Tissue Elastance | H | The parameter H is closely related to tissue elastance and reflects the energy conservation in the lung tissues. |
| Hysteresivity | eta | Tissue hysteresivity (η) characterizes the ratio of energy dissipation to energy conservation in the lung tissues. |
| Salazar-Knowles Parameter | A | The parameter A of the Salazar-Knowles equation is an upper bounds estimate of the difference between total lung capacity and zero volume. |
| Salazar-Knowles Parameter | B | The parameter B of the Salazar-Knowles equation is an upper bounds estimate of the difference between total lung capacity and the predicted volume at zero pressure. |
| Salazar-Knowles Parameter | K | The parameter K of the Salazar-Knowles equation reflects the curvature of the upper portion of the deflation PV curve. |
| Quasi-static Compliance | Cst | Quasi-static compliance reflects the static elastic recoil pressure of the lungs at a given lung volume. |
| Quasi-static Elastance | Est | Quasi-static elastance reflects the static elastic recoil pressure of the lungs at a given lung volume. |
| Enhanced Pause | Penh | Penh is an empirical measurement that is influenced by a number of factors, including, but not limited to bronchoconstriction. |
| Coefficient of Determination | COD | The COD is a quality control parameter measuring the goodness of the model fit. |
| Hysteresis | Hysteresis | Describes the difference in the pressure-volume relationship during the inflation and deflation curves of a pressure-volume loop. |